Key result
Obesity in middle-aged women was associated with significantly increased muscle sympathetic nerve activity and vascular resistance, and reduced muscle blood flow compared to lean women.
Why the study?
Does obesity increase muscle sympathetic nerve activity and alter hemodynamics in middle-aged normotensive women?
Cross-Sectional (n=26)
Does obesity increase muscle sympathetic nerve activity and alter hemodynamics in middle-aged normotensive women?
Obesity in middle-aged women is associated with increased sympathetic nerve activity and altered hemodynamics, which may explain their higher blood pressure levels.
Answers are grounded in this paper and cite their sources.
Supports sympathetic mechanisms in obesity-related hemodynamics; hypothesis-generating and requires prospective studies before clinical translation.
To study the relationship between the sympathetic nerve activity and hemodynamic alterations in obesity, we simultaneously measured muscle sympathetic nerve activity (MSNA), blood pressure, and forearm blood flow (FBF) in obese and lean individuals. Fifteen normotensive obese women (BMI = 32.5 +/- 0.5 kg/m2) and 11 age-matched normotensive lean women (BMI = 22.7 +/- 1.0 kg/m2) were studied. MSNA was evaluated directly from the peroneal nerve by microneurography, FBF was measured by venous occlusion plethysmography, and blood pressure was measured noninvasively by an autonomic blood pressure cuff. MSNA was significantly increased in obese women when compared with lean control women. Forearm vascular resistance and blood pressure were significantly higher in obese women than in lean women. FBF was significantly lower in obese women. BMI was directly and significantly correlated with MSNA, blood pressure, and forearm vascular resistance levels, but inversely and significantly correlated with FBF levels. Obesity increases sympathetic nerve activity and muscle vascular resistance, and reduces muscle blood flow. These alterations, taken together, may explain the higher blood pressure levels in obese women when compared with lean age-matched women.
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Ribeiro et al. (2001) conducted a cross-sectional in Obesity (n=26). Obesity vs. Lean individuals was evaluated on Muscle sympathetic nerve activity (MSNA), blood pressure, and forearm blood flow (FBF). Obesity in middle-aged women was associated with significantly increased muscle sympathetic nerve activity and vascular resistance, and reduced muscle blood flow compared to lean women.
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