Key result
Nicardipine treatment in renovascular hypertensive rats significantly reduced blood pressure (155 vs 208 mm Hg, p<0.01) and left ventricular mass (2.72 vs 3.10 mg/g, p<0.01).
Why the study?
Does nicardipine reduce left ventricular mass and improve haemodynamics in renovascular hypertensive rats?
Does nicardipine reduce left ventricular mass and improve haemodynamics in renovascular hypertensive rats?
In a rat model of renovascular hypertension, nicardipine reduced blood pressure and left ventricular mass but failed to normalize minimal coronary vascular resistance, suggesting blood pressure reduction alone may not fully reverse cardiac hypertrophy.
Nicardipine regresses LV mass via BP reduction in renovascular hypertensive rats; leaves open full hypertrophy reversal and human translation.
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Grellet et al. (1991) studied Renovascular hypertension (n=39). Nicardipine vs. Untreated hypertensive rats was evaluated on Blood pressure (p=<0.01). Nicardipine treatment in renovascular hypertensive rats significantly reduced blood pressure (155 vs 208 mm Hg, p<0.01) and left ventricular mass (2.72 vs 3.10 mg/g, p<0.01).
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