Key result
E. coli endotoxin injection in cats induced a drop in aortic pressure, cardiac acceleration, and increased cardiac and splenic sympathetic efferentation up to 1.4 and 10.6 times control levels.
Why the study?
Does E. coli endotoxin injection alter cardiovascular and autonomic nervous responses in anesthetized cats?
Does E. coli endotoxin injection alter cardiovascular and autonomic nervous responses in anesthetized cats?
In a feline model of endotoxin shock, early hemodynamic changes trigger significant sympathetic autonomic activation likely via cardiovascular receptors.
Suggests receptor-mediated sympathetic activation in feline endotoxin shock; leaves open translation to human sepsis.
Cardiovascular and autonomic nervous responses to an injection of E. coli endotoxin were followed for up to 15 min. in cats anesthetized with chloralose and given artificial respiration. Within 60 seconds, endotoxin induced a drop of aortic pressure, with simultaneous cardiac acceleration and slight central venous hypertension. There was an associated, almost complete cessation of the aortic arch baroreceptor afferentation. The cardiac sympathetic efferentation increased up to 1.4 times the control level at its maximum. The splenic sympathetic efferentation increased up to 10.6 times the control level at the end of the 15 min period, when the other parameters studied showed a trend to control level. The sympathetic autonomic system seems to be activated through cardiovascular receptors sensing hemodynamic changes touched off by endotoxin-induced release of vasoactive substances.
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Halinen et al. (1977) studied Endotoxin shock. E. coli endotoxin injection vs. Baseline/control level was evaluated on Cardiovascular and autonomic nervous responses. E. coli endotoxin injection in cats induced a drop in aortic pressure, cardiac acceleration, and increased cardiac and splenic sympathetic efferentation up to 1.4 and 10.6 times control levels.
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