Key result
The chicken B complex (MHC) is strongly associated with resistance to various infectious agents, including infectious bronchitis virus, in chickens.
Why the study?
Infectious bronchitis remains a global threat to poultry producers, and additional work was needed on the association between the chicken B complex and resistance to infectious bronchitis viruses.
This review highlights the role of the chicken B complex (MHC) in conferring genetic resistance to infectious bronchitis virus, emphasizing the need for further research in this area.
May support MHC-informed breeding for disease resistance in poultry; leaves open specific haplotype validation against infectious bronchitis virus.
Infectious bronchitis (IB) continues to be a global threat to poultry producers. The chicken major histocompatibility complex (MHC) or chicken B complex is compact, restricted to a single chromosome, and approximately 20-fold smaller than the mammalian MHC. Abundant evidence indicates that the B complex is strongly associated with resistance to various infectious agents in chickens. While an association between different B haplotypes and resistance against several bacterial and viral diseases has been established, additional work needs to be performed on the association between the B complex and resistance to IB viruses (IBV). Here, some of the available knowledge on genetic resistance to viral poultry diseases conferred by the chicken B locus is reviewed. IBV immune responses and resistance associated with differing B haplotype chicken lines are reviewed and discussed herein.
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A 2021 study conducted a review in Infectious bronchitis in chickens. Chicken B complex (MHC) haplotypes was evaluated. The chicken B complex (MHC) is strongly associated with resistance to various infectious agents, including infectious bronchitis virus, in chickens.
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