Key result
Balloon valvuloplasty effectively reduced the peak systolic aortic valve gradient in young adults from 73 to 30 mm Hg at follow-up (P<0.001), demonstrating similar efficacy to children.
Why the study?
Does balloon valvuloplasty effectively reduce peak systolic aortic valve gradient in young adults with congenital aortic stenosis compared to children?
Population
15 young adults and 70 children with congenital aortic stenosis.
Comparison
Percutaneous balloon valvuloplasty vs Children with congenital aortic stenosis…
Design
Cohort
Follow-up
1.2-2.5 years (mean 1.5 +/- 0.1 years)
Authors
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May support balloon valvuloplasty in young adults; extends pediatric data but leaves open need for randomized confirmation.
Cohort (n=85)
Does balloon valvuloplasty effectively reduce peak systolic aortic valve gradient in young adults with congenital aortic stenosis compared to children?
Absolute Event Rate: 30% vs 34%
p-value: p=< 0.001
Balloon valvuloplasty is an effective treatment for congenital aortic stenosis in young adults, providing gradient relief comparable to that achieved in children without early restenosis.
Sandhu et al. (1995) conducted a cohort in Congenital aortic stenosis (n=85). Balloon valvuloplasty vs. Children undergoing balloon valvuloplasty was evaluated on Peak systolic aortic valve gradient at follow-up (p=< 0.001). Balloon valvuloplasty effectively reduced the peak systolic aortic valve gradient in young adults from 73 to 30 mm Hg at follow-up (P<0.001), demonstrating similar efficacy to children.
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