Population
Heavy sarcoplasmic reticulum prepared from bovine ventricular muscle and unfractionated homogenate from rat…
Comparison
Gallopamil at concentrations ranging from 10 to… vs Control conditions and ryanodine
Design
Preclinical
Authors
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May support gallopamil's anti-ischemic effects via SR channels; hypothesis-generating and requires human validation before clinical consideration.
Gallopamil acts on cardiac SR calcium-release channels at therapeutic concentrations, which may contribute to its beneficial effects in myocardial ischemia.
Zucchi et al. (1992) studied this question.
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