Why the study?
Does gallopamil differ from verapamil in its mechanical and electrophysiological effects on isolated guinea-pig myocardium?
Population
Isolated guinea-pig myocardial preparations
Comparison
Gallopamil (D600) vs Verapamil
Design
Preclinical
Authors
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Gallopamil shows higher myocardial potency than verapamil in guinea pigs; leaves open clinical translation and differential use in humans.
Does gallopamil differ from verapamil in its mechanical and electrophysiological effects on isolated guinea-pig myocardium?
Gallopamil exhibits greater negative chronotropic and inotropic potency than verapamil in guinea-pig myocardium, likely due to mechanisms other than L-type calcium channel inhibition.
Noguchi et al. (1997) studied this question.
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