What question did this study set out to answer?

To evaluate whether baroreceptor-responsive neurons selectively cluster within the insular cortex, map their distribution, and determine whether their cardiovascular responses exhibit hemispheric lateralization.

June 1, 1997Brain ResearchOpen Access

Characterization, distribution and lateralization of baroreceptor-related neurons in the rat insular cortex

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Insular cortex cells during baroreceptor stimulation vs. Cells outside the insula (frontoparietal cortex). Primary outcome: Response to baroreceptor manipulations (p=<0.0001).

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Key result

Insular cortex cells were significantly more likely to respond to baroreceptor stimulation than cells in the surrounding frontoparietal cortex (70% vs 32%, P<0.0001).

Population

34 urethane-anesthetized male Sprague-Dawley rats

Comparison

Baroreceptor stimulation with phenylephrine and… vs Surrounding frontoparietal cortex and left vs…

Design

Preclinical

Authors

ZZZhihua ZhangMackay Base Hospital SOStephen M. OppenheimerJohns Hopkins University

Discussion

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Implication

Should not change clinical practice; leaves open insular baroreceptor mapping as a therapeutic target in humans.

Key Points

To evaluate whether baroreceptor-responsive neurons selectively cluster within the insular cortex, map their distribution, and determine whether their cardiovascular responses exhibit hemispheric lateralization.
Extracellular recordings were obtained from 128 insular neurons and 57 adjacent frontoparietal cortical neurons in 34 urethane-anesthetized male Sprague-Dawley rats.
Baroreceptors were pharmacologically stimulated using phenylephrine and sodium nitroprusside to characterize neuronal activity as sympathoexcitatory, sympathoinhibitory, or null.
A significantly greater proportion of insular neurons responded to baroreceptor manipulation compared to neurons in the surrounding cortex (70% vs. 32%, P < 0.0001), with most identified as sympathoexcitatory.
Responsive neurons were distributed extensively throughout the insular cortex, with significantly greater responsiveness observed in the right rostral posterior insula than in the left (P < 0.003).

Structured PICO

Population

34 urethane-anesthetized male Sprague-Dawley rats undergoing baroreceptor stimulation to assess insular cortex cell responses.

Intervention

Baroreceptor stimulation with phenylephrine and sodium nitroprusside

Comparator

Surrounding frontoparietal cortex (cells outside the insula) and left vs right posterior insula

Outcome

Cellular response to baroreceptor manipulations (characterization as sympathoexcitatory, sympathoinhibitory, or null cells)surrogate

Main Result

Absolute Event Rate: 70% vs 32%

p-value: p=<0.0001

This preclinical study demonstrates that baroreceptor-responsive neurons are widely distributed in the rat insular cortex and lateralized to the right posterior insula, highlighting its role in cardiovascular control.

Cite This Study

Zhang et al. (1997) studied this question. Insular cortex cells during baroreceptor stimulation vs. Cells outside the insula (frontoparietal cortex) was evaluated on Response to baroreceptor manipulations (p=<0.0001). Insular cortex cells were significantly more likely to respond to baroreceptor stimulation than cells in the surrounding frontoparietal cortex (70% vs 32%, P<0.0001).

synapsesocial.com/papers/6a942e018e5b8037ce4409af https://doi.org/10.1016/s0006-8993(97)00284-9

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Characterization, distribution and lateralization of baroreceptor-related neurons in the rat insular cortex

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Characterization, distribution and lateralization of baroreceptor-related neurons in the rat insular cortex

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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