Key result
Rotavirus nonstructural protein NSP3 binds to the 3' end consensus sequence of rotavirus mRNAs in infected cells.
Population
rotavirus-infected cells
Design
Preclinical
Authors
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No direct clinical implications from this animal study; leaves open NSP3-mRNA binding as a potential antiviral target.
Demonstrates that rotavirus protein NSP3 binds to the 3' end consensus sequence of viral mRNAs in infected cells.
Poncet et al. (1993) studied Rotavirus infection. UV cross-linking and immunoprecipitation was evaluated on Interaction between viral proteins and RNAs. Rotavirus nonstructural protein NSP3 binds to the 3' end consensus sequence of rotavirus mRNAs in infected cells.
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