Population
Rotavirus-infected cells, yeast two-hybrid system, and murine rotavirus strain EW
Design
Preclinical
Authors
Loading...
May explain rotavirus interferon evasion; leaves open whether NSP1-IRF-3 disruption alters pathogenesis or offers antiviral targets.
The interaction between rotavirus NSP1 and IRF-3 suggests that NSP1 may function to inhibit IRF-3 activation and diminish the cellular interferon response.
Graff et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: