Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3

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Population

Cell cultures (MA104, 293T, FRhL2, Caco-2 cells) infected with rotavirus strains

Comparison

Rotavirus expressing wild-type nonstructural… vs Rotavirus expressing C-truncated forms of NSP1…

Design

Preclinical

Authors

Discussion

Should not yet inform clinical rotavirus management; leaves open whether NSP1 inhibition restores IFN responses in vivo.

Population

Cell cultures (MA104, 293T, FRhL2, Caco-2 cells) infected with rotavirus strains

Intervention

Rotavirus expressing wild-type nonstructural protein 1 (NSP1)

Comparator

Rotavirus expressing C-truncated forms of NSP1 or mock infection

Outcome

IRF3 degradation, dimerization, nuclear translocation, and IFN promoter activitysurrogate

Rotavirus subverts the innate immune response by using its nonstructural protein 1 (NSP1) to induce the proteasome-dependent degradation of IRF3.

Barro et al. (2005) studied this question.

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