Key result
Heterologous rotaviruses fail to degrade cellular IRF3, leading to restricted replication in IFN-competent cells, whereas homologous strains efficiently degrade IRF3 and replicate without restriction.
Population
Mouse embryonic fibroblast model
Comparison
Infection with homologous murine rotaviruses or… vs Infection with heterologous bovine and porcine…
Design
Preclinical
Authors
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Does not inform human rotavirus management; leaves open NSP1 variation as a host-range determinant.
There is a direct relationship between the replication efficiencies of different rotavirus strains in MEFs and strain-related variations in NSP1-mediated antagonism of the type I IFN response.
Feng et al. (2009) studied Rotavirus infection. Rotavirus strains (homologous vs heterologous) vs. Wild-type vs IFN-deficient mouse embryonic fibroblasts was evaluated on Viral replication and IRF3 degradation/IFN-beta secretion. Heterologous rotaviruses fail to degrade cellular IRF3, leading to restricted replication in IFN-competent cells, whereas homologous strains efficiently degrade IRF3 and replicate without restriction.
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