Key result
Rotavirus NSP1 proteins from different strains impeded IFN-beta expression through diverse mechanisms, with human strains predominantly degrading IRF5 and IRF7, and animal strains targeting IRF3, IRF5, and IRF7.
Population
African green monkey kidney MA104 cells, Human colon HT29 cells, and Human 293T cells
Comparison
Infection with various rotavirus strains or… vs Mock-infected cells or empty vector-transfected…
Design
Preclinical
Follow-up
10 to 36 hours post-infection/transfection
Authors
Loading...
May guide mechanism-based antivirals; leaves open translation from animal models to human disease.
Rotaviruses exhibit diverse mechanisms for subverting the host antiviral response, with human strains predominantly targeting IRF5 and IRF7, while animal strains target IRF3, IRF5, and IRF7.
Arnold et al. (2010) studied Rotavirus infection. Rotavirus NSP1 proteins vs. Mock infection or empty vector was evaluated on Inhibition of IFN-beta expression and degradation of IRF3, IRF5, IRF7, and beta-TrCP. Rotavirus NSP1 proteins from different strains impeded IFN-beta expression through diverse mechanisms, with human strains predominantly degrading IRF5 and IRF7, and animal strains targeting IRF3, IRF5, and IRF7.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: