This review highlights the role of rotavirus NSP1 in evading the host innate immune response and the remaining questions regarding its mechanism.
May guide rotavirus antiviral development; leaves open NSP1 mechanism and replication role.
Rotavirus is a leading cause of death due to diarrhea among young children across the globe. Despite the limited coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding the host innate immune response. Among these strategies is use of the interferon antagonist protein NSP1, which targets cellular proteins required for interferon production to be degraded by the proteasome. Although numerous cellular targets have been described, there remain many questions about the mechanism of NSP1 activity and its role in promoting replication in specific host species.
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Michelle M. Arnold (2016) studied this question.
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