Key result
Clonidine (200 µg) produced a significantly greater reduction in blood pressure compared to moxonidine (200 µg) in healthy normotensive males (95% CI 3.2-12.2), though moxonidine had fewer adverse effects.
Why the study?
Does a single oral dose of moxonidine or clonidine reduce blood pressure and alter behavioural responses compared to placebo in healthy normotensive males?
Population
Healthy normotensive males
Comparison
Single oral dose of moxonidine or clonidine vs Placebo
Design
RCT, randomised crossover, double-blind
Follow-up
over the study day
Authors
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Moxonidine's better tolerability versus clonidine's greater BP reduction favors its selection when minimizing adverse effects; extends comparative data on central imidazoline agonists.
RCT
Double-blind
randomized
Does a single oral dose of moxonidine or clonidine reduce blood pressure and alter behavioural responses compared to placebo in healthy normotensive males?
A single 200 microgram dose of moxonidine produces less hypotension and fewer adverse effects than an equivalent dose of clonidine in healthy normotensive males.
Macphee et al. (1992) conducted an RCT in Healthy normotensive. Moxonidine and clonidine vs. Placebo was evaluated on Blood pressure reduction (95% CI 3.2-12.2). Clonidine (200 µg) produced a significantly greater reduction in blood pressure compared to moxonidine (200 µg) in healthy normotensive males (95% CI 3.2-12.2), though moxonidine had fewer adverse effects.
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