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Early stages of concurrent pregnancy during lactation had relatively little effect on lactational performance (litter weight gain), deoxyribonucleic acid (cell numbers), ribonucleic acid (protein synthetic acivity), hydroxyproline (collagen), and hexosamine (ground substance) content of the mammary glands of rats. However, during advanced stages of pregnancy, litter weight gains were depressed. This decreased lactational performance was associated with reduced mammary deoxyribonucleic acid, ribonucleic acid, and hydroxyproline, but not hexosamine content.
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Paape et al. (1969) studied this question.
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