Key result
Gene 1 of the atypical human rotavirus strain E210 showed greatest sequence identity to a Taiwanese isolate (TE83) and relatedness to other Australian and Japanese strains.
E210's regional genetic ties warrant expanded rotavirus surveillance; leaves open vaccine and transmission implications.
Gene 1 (which encodes the viral RNA-dependent RNA polymerase, VP1) of an atypical human reassortant rotavirus strain, E210 (serotype G2P1B), is unrelated to genes 1 of standard human rotaviruses. To ascertain the origin of this gene, we determined a partial sequence and found that it exhibited greatest identity to gene 1 of a Taiwanese isolate, TE83, which is representative of G2 strains that caused an epidemic of gastroenteritis in 1993. Limited sequence identity to genes 1 of standard human and animal viruses was observed. This was confirmed by phylogenetic analysis. However, hybridization analysis using an E210 gene 1-specific probe indicated that a related gene was found among other Australian G2 isolates and in a Japanese strain isolated in the 1970s.
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Masendycz et al. (2001) studied Rotavirus infection. Genetic sequencing and hybridization analysis vs. Standard human and animal rotaviruses was evaluated on Genetic relatedness of VP1 gene. Gene 1 of the atypical human rotavirus strain E210 showed greatest sequence identity to a Taiwanese isolate (TE83) and relatedness to other Australian and Japanese strains.
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