Key result
Fragmented QRS was significantly more frequent in non-dipper versus dipper hypertension (56% vs 19.6%) and independently predicted non-dipper status (OR 5.207; 95% CI 2.195-12.353; P<0.001).
Why the study?
Is fragmented QRS associated with non-dipper status in hypertensive patients without left ventricular hypertrophy?
Observational (n=106)
Is fragmented QRS associated with non-dipper status in hypertensive patients without left ventricular hypertrophy?
Odds Ratio: 5.207 (95% CI 2.195–12.353)
Absolute Event Rate: 56% vs 19.6%
p-value: p=<0.001
Fragmented QRS on surface ECG is an independent predictor of non-dipper status in hypertensive patients without LVH, suggesting its potential utility as a simple marker for this higher-risk blood pressure pattern.
Supports fQRS as a marker for non-dipper hypertension without LVH; hypothesis-generating and requires prospective validation.
BACKGROUND: Fragmented QRS (fQRS) has been shown to be associated with poor outcome in various cardiovascular diseases. Non-dipper hypertension is also associated with increased cardiovascular mortality. The aim of our study is to investigate the relationship between fQRS and non-dipper status in hypertensive patients without left ventricular hypertrophy (LVH). METHODS: This study included 106 hypertensive patients without LVH. Patients were divided into two groups: dipper hypertension and non-dipper hypertension. The presence of fQRS was analyzed from surface electrocardiography. RESULTS: Frequency of fQRS (56% vs. 19.6%, p < 0.001) and mean number of leads with fQRS (1.9 ± 1.7 vs. 0.6 ± 1.0, p < 0.001) were significantly higher in patients with non-dipper hypertension compared to dipper hypertension. In addition, the number of leads with fQRS was positively correlated with systolic (r = 0.334, p < 0.001) and diastolic (r = 0.280, p = 0.004) blood pressures (BP). By a multivariate regression analysis, fQRS (OR: 5.207, 95% CI: 2.195-12.353, p < 0.001) was found to be independent predictor of non-dipper status. CONCLUSION: fQRS is independent predictor of non-dipper status in hypertensive patients without LVH. Also, the higher number of leads with fQRS is associated with higher sleep systolic and diastolic BPs.
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Tanrıverdi et al. (2017) conducted an observational in Hypertension without left ventricular hypertrophy (n=106). Non-dipper hypertension vs. Dipper hypertension was evaluated on Presence of fragmented QRS (fQRS) (OR 5.207, 95% CI 2.195-12.353, p=<0.001). Fragmented QRS was significantly more frequent in non-dipper versus dipper hypertension (56% vs 19.6%) and independently predicted non-dipper status (OR 5.207; 95% CI 2.195-12.353; P<0.001).
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