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April 1, 1995Postgraduate Medical JournalOpen Access

Severe theophylline poisoning: charcoal haemoperfusion or haemodialysis?

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Key result

Combined charcoal haemoperfusion and haemodialysis achieved a mean theophylline extraction rate of 86%, compared to 26% during continuous arteriovenous haemodialysis.

Population

1 38-year-old man with severe theophylline poisoning complicated by circulatory collapse, rhabdomyolysis…

Design

Case_report

Authors

RHR. HigginsEuropean Centre for Information on Marine Science and TechnologySHStephen HearingRoyal Derby HospitalDGDavid GoldsmithEmory University

Discussion

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Implication

May enhance theophylline clearance in poisoning; leaves open whether combined therapy improves outcomes over haemodialysis alone.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 38-year-old man with severe theophylline poisoning (blood level 183 mg/l) who developed circulatory collapse, rhabdomyolysis, acute renal failure, and hyperthermia.
I
Intervention
Charcoal haemoperfusion and simultaneous haemodialysis, followed by continuous arteriovenous haemodialysis (CAVHD)
O
Outcome
Theophylline extraction ratessurrogate

Main Result

Absolute Event Rate: 86% vs 26%

A combination of charcoal haemoperfusion and haemodialysis provides the best clearance for severe theophylline poisoning, though haemodialysis alone may also be effective.

Cite This Study

Higgins et al. (1995) conducted a case report in Severe theophylline poisoning (n=1). Charcoal haemoperfusion and simultaneous haemodialysis vs. Continuous arteriovenous haemodialysis (CAVHD) was evaluated on Mean extraction rates of theophylline. Combined charcoal haemoperfusion and haemodialysis achieved a mean theophylline extraction rate of 86%, compared to 26% during continuous arteriovenous haemodialysis.

synapsesocial.com/papers/6a944e55175d68f85fc577ffhttps://doi.org/10.1136/pgmj.71.834.224
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