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June 1, 1982Therapeutic Drug Monitoring

Hemodialysis Clearance of Theophylline

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Why the study?

How does hemodialysis affect the clearance of theophylline in patients?

Population

4 patients receiving theophylline and undergoing hemodialysis

Comparison

Hemodialysis (hollow fiber systems) vs Systemic serum clearance off dialysis

Design

Case_series

Authors

RSRichard L. SlaughterBuffalo State UniversityLGLaurence GreenBrigham and Women's HospitalRKRomesh Kohli

Discussion

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Implication

HD substantially increases theophylline clearance; Level 5 case report leaves open need for adjusted dosing or monitoring.

Structured PICO

How does hemodialysis affect the clearance of theophylline in patients?

P
Population
4 patients receiving theophylline and undergoing hemodialysis
I
Intervention
Hemodialysis (hollow fiber systems)
C
Comparator
Systemic serum clearance off dialysis (in 3 patients)
O
Outcome
Serum hemodialysis clearance of theophyllinesurrogate

Hemodialysis significantly increases theophylline clearance, necessitating close monitoring and potential dosage increases during the procedure.

Cite This Study

Slaughter et al. (1982) studied this question.

synapsesocial.com/papers/6a71cbece36a167817e37dbdhttps://doi.org/10.1097/00007691-198206000-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonlinear theophylline elimination1982 · 153 citations
  2. 2Severe theophylline poisoning: charcoal haemoperfusion or haemodialysis?1995 · 26 citations
  3. 3Impaired theophylline clearance in patients with cor pulmonale.1979 · 55 citations
  4. 4Theophylline kinetics in acute pulmonary edema1977 · 156 citations
  5. 5Intravenous Theophylline Therapy: Nomogram Guidelines1977 · 102 citations