What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) (n=1541). Intervention: Impaired fasting glucose and impaired glucose tolerance vs. Normal glucose tolerance. Primary outcome: Cardiovascular risk factors including pulse-wave velocity (PWV).

What question did this study set out to answer?

To evaluate and compare cardiovascular risk factors, including arterial stiffness via pulse-wave velocity, in Japanese individuals with isolated impaired fasting glucose versus isolated impaired glucose tolerance using 1997 and 2003 ADA criteria.

August 25, 2006Diabetes Care

Atherosclerotic Risk Factors in Japanese Subjects With Isolated Impaired Fasting Glucose and Those With Isolated Impaired Glucose Tolerance According to 1997 and 2003 American Diabetes Association Criteria

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Key result

Cardiovascular risk factors including pulse-wave velocity were evaluated in subjects with IFG and IGT, but quantitative results are not reported in the truncated abstract.

Why the study?

Do cardiovascular risk factors and arterial stiffness differ between Japanese subjects with isolated impaired fasting glucose and those with isolated impaired glucose tolerance?

Population

1,541 Japanese subjects undergoing periodic health examinations at a single center

Comparison

Isolated impaired fasting glucose or isolated… vs Normal glucose tolerance or other glucose…

Design

Cross-sectional

Authors

SMShinya MoritaKeio University SKSoji KasayamaNippon Medical School Hospital MOMichio OtsukiShimane University

Discussion

Member takes

Implication

Arterial stiffness differences between isolated IFG and IGT remain unresolved in Japanese adults; leaves open targeted CV risk stratification by prediabetes subtype.

Key Points

To evaluate and compare cardiovascular risk factors, including arterial stiffness via pulse-wave velocity, in Japanese individuals with isolated impaired fasting glucose versus isolated impaired glucose tolerance using 1997 and 2003 ADA criteria.
Evaluated 1,541 Japanese subjects undergoing periodic health examinations at Kinki Central Hospital between April and October 2003.
Classified glucose tolerance status based on 1997 and 2003 American Diabetes Association diagnostic criteria.
Assessed cardiovascular risk factors and arterial stiffness using noninvasive pulse-wave velocity measurements.
Cardiovascular risk profiles and arterial stiffness measures were contrasted between isolated impaired fasting glucose and isolated impaired glucose tolerance cohorts.
Diagnostic reclassification between 1997 and 2003 ADA criteria altered the identification and risk stratification of subjects with abnormal glucose metabolism.

Study Design

Type

Cross-Sectional (n=1,541)

Multicenter

Structured PICO

Do cardiovascular risk factors and arterial stiffness differ between Japanese subjects with isolated impaired fasting glucose and those with isolated impaired glucose tolerance?

Population

1,541 Japanese subjects undergoing periodic health examinations evaluated for cardiovascular risk factors based on IFG and IGT criteria.

Exposure

Isolated impaired fasting glucose (IFG) or isolated impaired glucose tolerance (IGT) according to 1997 and 2003 American Diabetes Association criteria

Comparator

Normal glucose tolerance (NGT) or other glucose metabolism categories

Outcome

Cardiovascular risk factors including pulse-wave velocity (PWV)surrogate

This study evaluates differences in atherosclerotic risk factors, including arterial stiffness, between different categories of prediabetes in a Japanese population.

Cite This Study

Morita et al. (2006) conducted a cross-sectional in Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) (n=1,541). Impaired fasting glucose and impaired glucose tolerance vs. Normal glucose tolerance was evaluated on Cardiovascular risk factors including pulse-wave velocity (PWV). Cardiovascular risk factors including pulse-wave velocity were evaluated in subjects with IFG and IGT, but quantitative results are not reported in the truncated abstract.

synapsesocial.com/papers/6a9451a4fde2ed39e1a0cc2f https://doi.org/10.2337/dc06-0964

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Implication

Arterial stiffness differences between isolated IFG and IGT remain unresolved in Japanese adults; leaves open targeted CV risk stratification by prediabetes subtype.

Atherosclerotic Risk Factors in Japanese Subjects With Isolated Impaired Fasting Glucose and Those With Isolated Impaired Glucose Tolerance According to 1997 and 2003 American Diabetes Association Criteria

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Atherosclerotic Risk Factors in Japanese Subjects With Isolated Impaired Fasting Glucose and Those With Isolated Impaired Glucose Tolerance According to 1997 and 2003 American Diabetes Association Criteria

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider