Key result
Patients with IgA nephropathy had a higher frequency of the ACE DD genotype than the normal population, but this polymorphism was not associated with the rate of disease progression.
Observational (n=177)
In patients with IgA nephropathy, specific genetic polymorphisms (ACE DD genotype and IL1RN*2 allele) may be associated with disease susceptibility and specific clinical manifestations like macroscopic haematuria, though larger studies are needed.
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ACE DD genotype may signal IgA nephropathy susceptibility but not progression; leaves open its prognostic value pending larger prospective studies.
Lei‐Shi LI (1997) conducted an observational in IgA nephropathy (n=177). ACE and IL-1ra gene polymorphisms vs. Normal population was evaluated on Genotype frequency and rate of progression of IgAN. Patients with IgA nephropathy had a higher frequency of the ACE DD genotype than the normal population, but this polymorphism was not associated with the rate of disease progression.
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