Key result
Genomic approaches identify multiple susceptibility loci linked to IgA nephritis pathogenesis and progression.
Why the study?
Genomic factors in the pathogenesis and progression of IgA nephritis remain incompletely understood, with controversial findings regarding ACE gene polymorphism and other genetic loci.
Genomic approaches are unraveling the complex pathogenesis of IgA nephritis, identifying new susceptibility loci and potentially guiding targeted therapies such as high-dose ARBs based on genotype.
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High-dose ARB may blunt ACE DD genotype risk in IgAN; leaves open whether genotyping should guide therapy.
Woo et al. (2013) conducted a review in IgA Nephritis. Genomic profiling and association studies was evaluated. Genomic approaches, including microarrays and genome-wide association studies, have identified multiple susceptibility loci and genes involved in the pathogenesis and progression of IgA nephritis.
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