Key result
Sevoflurane anesthesia significantly reduced the low frequency power of systolic blood pressure variability from 2.6 to 0.3 mmHg^2 (p<0.001), reflecting decreased sympathetic vasomotor activity.
Why the study?
Does general anesthesia with sevoflurane alter blood pressure variability in healthy living-liver transplantation donors?
Observational (n=15)
No
Does general anesthesia with sevoflurane alter blood pressure variability in healthy living-liver transplantation donors?
Absolute Event Rate: 0.3% vs 2.6%
p-value: p=<0.001
Sevoflurane anesthesia significantly diminishes low frequency blood pressure variability in healthy individuals.
Sevoflurane was associated with reduced sympathetic vasomotor activity in healthy donors; leaves open effects on perioperative outcomes and requires randomized confirmation.
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Hwang et al. (2005) conducted an observational in Healthy living liver transplantation donors (n=15). Sevoflurane anesthesia vs. Conscious baseline was evaluated on Low frequency (LF) power of systolic blood pressure variability (SBPV) (p=<0.001). Sevoflurane anesthesia significantly reduced the low frequency power of systolic blood pressure variability from 2.6 to 0.3 mmHg^2 (p<0.001), reflecting decreased sympathetic vasomotor activity.
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