Key result
High-level spinal cord injury at Th3 or above eliminates normal neural cardiovascular responses to mild orthostatic stress, causing a significant fall in systolic blood pressure (-10 +/- 4 mm Hg, P<.05).
Why the study?
Does the level of spinal cord injury affect neural cardiovascular regulations in response to orthostatic stress?
Population
26 patients with varying levels of spinal cord injury (C4 to Th12) and 15 healthy control subjects.
Comparison
60 degree head-up position (orthostatic stress) vs Rest position and healthy control subjects
Design
Cross-sectional
Authors
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May support orthostatic monitoring in high-level SCI; leaves open prospective validation of mechanisms and interventions.
Observational (n=41)
Does the level of spinal cord injury affect neural cardiovascular regulations in response to orthostatic stress?
Effect estimate: -10 +/- 4 mm Hg
p-value: p=< .05
Spinal cord injury at Th3 or above eliminates normal neural cardiovascular responses to mild orthostatic stress, leading to orthostatic hypotension.
Masanori Munakata (2001) conducted an observational in Spinal cord injury (n=41). High-level spinal cord injury (Th3 or above) vs. Low-level spinal cord injury (Th4 or below) and healthy controls was evaluated on Change in systolic blood pressure with postural shift (-10 +/- 4 mm Hg, p=< .05). High-level spinal cord injury at Th3 or above eliminates normal neural cardiovascular responses to mild orthostatic stress, causing a significant fall in systolic blood pressure (-10 +/- 4 mm Hg, P<.05).
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