Key result
Xuefu Zhuyu Capsule combined with conventional drugs improved angina symptom relief compared to conventional drugs alone.
Why the study?
Does Xuefu Zhuyu Capsule combined with conventional drugs improve angina symptoms and ECG findings in patients with unstable angina?
Systematic Review
Does Xuefu Zhuyu Capsule combined with conventional drugs improve angina symptoms and ECG findings in patients with unstable angina?
Xuefu Zhuyu Capsule combined with conventional drugs may improve angina symptoms and ECG findings in patients with unstable angina, though more rigorous trials are needed.
Answers are grounded in this paper and cite their sources.
May support adjunctive use for angina relief in unstable angina; extends meta-analytic data but requires larger rigorous RCTs.
BACKGROUND: Xuefu Zhuyu Capsule (XFZY) has been commonly used for relieving chest pain in patients with coronary heart disease (CHD). Randomized controlled trials (RCTs) on XFZY in treating unstable angina (UA) have not been systematically reviewed. OBJECTIVE: This study aims to provide a PRISMA-compliant systematic review to evaluate the efficacy of XFZY in treating UA. METHODS: An extensive search of 7 medical databases was performed up to June 2013. RCTs involving XFZY or combined with conventional drugs versus conventional drugs were identified. Meta-analysis was performed to evaluate the cardiovascular effects of XFZY. Rev Man 5.0 was used for data analysis. RESULTS: 8 RCTs were included in this review. Statistical analysis of the results showed that XFZY combined with conventional drugs had significant effect on relieving angina symptoms (RR: 1.26 [1.16, 1.38]; P<0.00001) and improving ECG (RR: 1.20 [1.04, 1.38]; P=0.01) compared with conventional drugs alone. No severe adverse events were reported. CONCLUSIONS: XFZY combined with conventional drugs appears to have potential cardiovascular effects in treatment of UA with few adverse events. However, further rigorous designed trials are still needed.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2014) conducted a systematic review in Unstable angina pectoris. Xuefu Zhuyu Capsule (XFZY) combined with conventional drugs vs. Conventional drugs alone was evaluated on Relieving angina symptoms (RR 1.26, 95% CI 1.16, 1.38, p=<0.00001). Xuefu Zhuyu Capsule combined with conventional drugs improved angina symptom relief compared to conventional drugs alone.
Synapse has enriched 10 related papers. Consider them for comparative context: