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August 15, 2009Journal of Chinese Integrative Medicine

A randomized double-blinded controlled trial of Xuefu Zhuyu Capsule on short-term quality of life in unstable anginal patients with blood-stasis syndrome after percutaneous coronary intervention

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Key result

Xuefu Zhuyu Capsule significantly improved multiple domains of health-related quality of life compared to Shengmai Capsule and placebo in unstable angina patients after PCI (P<0.05).

Why the study?

Does Xuefu Zhuyu Capsule improve health-related quality of life in unstable angina patients with blood-stasis syndrome after PCI?

Population

90 patients diagnosed with unstable angina and concomitant blood stasis syndrome after successful…

Comparison

Xuefu Zhuyu Capsule administered for 4 weeks vs Shengmai Capsule or placebo administered for 4…

Design

RCT, randomized, double-blinded, double-dummy, placebo controlled

Follow-up

4 weeks

Authors

FCFY Chu

Discussion

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Overview

Supports short-term Xuefu Zhuyu Capsule use post-PCI in unstable angina; extends RCT evidence for TCM in blood-stasis syndrome.

Study Design

Type

RCT (n=90)

Blinding

Double-blind, double-dummy

Randomization

randomized

Multicenter

No

Structured PICO

Does Xuefu Zhuyu Capsule improve health-related quality of life in unstable angina patients with blood-stasis syndrome after PCI?

P
Population
90 patients with unstable angina and blood-stasis syndrome after successful PCI, treated for 4 weeks.
I
Intervention
Xuefu Zhuyu (XFZY) Capsule administered for 4 weeks
C
Comparator
Shengmai (SM) Capsule or placebo (double-dummy design) administered for 4 weeks
O
Outcome
Health-related quality of life (HR-QoL) assessed by Short-Form 36 (SF-36) and Seattle Angina Questionnaire (SAQ) after 4 weeks of treatmentpatient reported

Main Result

p-value: p=<0.05

A 4-week treatment with Xuefu Zhuyu Capsule improved short-term health-related quality of life in patients with unstable angina and blood-stasis syndrome following PCI.

Limitations

  • Long-term efficacy and safety needs further investigation.
  • long-term efficacy and safety needs further investigation

Cite This Study

FY Chu (2009) conducted an RCT in Unstable angina with blood-stasis syndrome after PCI (n=90). Xuefu Zhuyu Capsule vs. Shengmai Capsule and placebo was evaluated on Health-related quality of life assessed by SF-36 and SAQ (p=<0.05). Xuefu Zhuyu Capsule significantly improved multiple domains of health-related quality of life compared to Shengmai Capsule and placebo in unstable angina patients after PCI (P<0.05).

synapsesocial.com/papers/6aa6cb9550dab972bddd737chttps://doi.org/10.3736/jcim20090805
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction: Executive Summary and Recommendations2000 · 4,505 citations