Key result
Metabolic inhibitors and low internal pH differentially inhibited inward rectifier K+ channels, with Kir2.3 being the most sensitive to pH (pK=6.9) and FCCP, while Kir2.1 was the least sensitive.
Population
Xenopus oocytes heterologously expressing inward rectifier K(+) channels K(ir)2.1, K(ir)2.2, and K(ir)2.3
Comparison
Metabolic inhibitors and lowered internal pH vs Different channel subtypes (K2.1 vs K2.2 vs…
Design
Preclinical
Authors
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May modulate ischemia-related arrhythmia risk; leaves open translation of subtype differences to human electrophysiology.
Inward rectifier K+ channels exhibit differential sensitivity to metabolic inhibition and internal pH, which may influence the electrophysiological response and arrhythmia risk during cardiac ischemia.
Collins et al. (2002) studied Ischemia simulation. Metabolic inhibitors (FCCP, NaN3) and low pH was evaluated on Inhibition of inward rectifier K+ channels (Kir2.1, Kir2.2, Kir2.3). Metabolic inhibitors and low internal pH differentially inhibited inward rectifier K+ channels, with Kir2.3 being the most sensitive to pH (pK=6.9) and FCCP, while Kir2.1 was the least sensitive.
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