Key result
High disease activity in systemic lupus erythematosus was associated with significantly increased QT dispersion compared to low disease activity (58.31 vs 47.90 ms, p<0.004).
Why the study?
Does high disease activity increase QT dispersion in patients with systemic lupus erythematosus?
Cross-Sectional (n=104)
Blinded assessors
No
Does high disease activity increase QT dispersion in patients with systemic lupus erythematosus?
Absolute Event Rate: 58.31% vs 47.9%
p-value: p=<0.004
In patients with systemic lupus erythematosus, high disease activity (SLEDAI > 10) is associated with significantly increased QT dispersion, suggesting it may serve as an early marker for subclinical cardiac involvement.
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May flag subclinical cardiac involvement in active SLE; leaves open prospective validation as arrhythmia marker.
Kojuri et al. (2012) conducted a cross-sectional in Systemic lupus erythematosus (n=104). High disease activity (SLEDAI > 10) vs. Low to moderate disease activity (SLEDAI ≤ 10) was evaluated on QT dispersion (p=<0.004). High disease activity in systemic lupus erythematosus was associated with significantly increased QT dispersion compared to low disease activity (58.31 vs 47.90 ms, p<0.004).
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