Key result
Dietary chrysin alleviated adiposity and insulin resistance while promoting subcutaneous adipocyte browning and systemic energy expenditure in high-fat diet-fed mice.
Why the study?
Activation of adipose tissue browning and thermogenesis provides a potential strategy to counter obesity and associated metabolic diseases.
Does dietary chrysin alleviate adiposity and insulin resistance by stimulating subcutaneous fat thermogenesis in HFD-fed mice?
Does dietary chrysin alleviate adiposity and insulin resistance by stimulating subcutaneous fat thermogenesis in HFD-fed mice?
Dietary chrysin promotes subcutaneous adipocyte browning and systemic energy expenditure in HFD-fed mice, suggesting a potential strategy against obesity and metabolic diseases.
Hypothesis-generating for chrysin in obesity; human trials required before clinical consideration.
The activation of adipose tissue browning and thermogenesis provides a new strategy to counter obesity and associated metabolic diseases. Here, a natural flavonoid chrysin is used as the supplement of a high-fat diet (HFD). Dietary chrysin alleviates adiposity and insulin resistance in HFD-fed mice. Meanwhile, dietary chrysin elevates systemic energy expenditure and enhances the uncoupling protein-1 (UCP1) level in subcutaneous adipose tissue (SAT), which is accompanied by the increased thermogenic program, beige preadipocyte number, and angiogenesis in SAT. Dietary chrysin also induces the expression of SAT platelet-derived growth factor receptor α (PDGFRα), which commits adipose progenitor cells to differentiate into beige or white adipocytes in response to various environmental signals. Double immunofluorescent staining for UCP1 and PDGFRα reveals that chrysin elevates the number of UCP1 + PDGFRα + beige progenitors in SAT. Further, chrysin treatment reverses the effects of the specific PDGFRα inhibitor imatinib on browning differentiation of stromal vascular fraction cells from SAT. Finally, chrysin-induced adipocyte browning is correlated with the expressions of microRNAs as PDGFRα inhibitors or thermogenesis suppressors. In conclusion, dietary chrysin promotes subcutaneous adipocyte browning and systematic energy expenditure by regulating PDGFRα and microRNA expressions in HFD-fed mice.
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Wang et al. (2021) studied Obesity and insulin resistance. Dietary chrysin vs. High-fat diet alone was evaluated on Adiposity, insulin resistance, and subcutaneous adipocyte browning. Dietary chrysin alleviated adiposity and insulin resistance while promoting subcutaneous adipocyte browning and systemic energy expenditure in high-fat diet-fed mice.
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