Key result
Postoperative fluid substitution with dextran and crystalloids resulted in equal hydroxyproline content on day 7 compared to crystalloids alone, showing no advantage for granulation tissue formation.
Why the study?
Does postoperative fluid replacement with dextran and crystalloids improve granulation tissue formation compared to crystalloids alone in patients undergoing major abdominal surgery?
Population
29 patients subjected to major abdominal surgery
Comparison
Postoperative fluid replacement with a… vs Postoperative fluid replacement with…
Design
RCT, randomized
Follow-up
7 days
Authors
Loading...
Dextran adds no granulation tissue benefit over crystalloids; challenges colloid use in optimized postoperative fluid management.
RCT (n=29)
Does postoperative fluid replacement with dextran and crystalloids improve granulation tissue formation compared to crystalloids alone in patients undergoing major abdominal surgery?
Postoperative fluid substitution with dextran offers no advantage over crystalloids alone for granulation tissue formation when fluid support is optimized according to subcutaneous oxygen tension.
Hartmann et al. (2008) conducted an RCT in major abdominal surgery (n=29). Crystalloids and colloids (dextran 70) vs. Crystalloids only was evaluated on Hydroxyproline content on day 7. Postoperative fluid substitution with dextran and crystalloids resulted in equal hydroxyproline content on day 7 compared to crystalloids alone, showing no advantage for granulation tissue formation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: