Answers are grounded in this paper and cite their sources.
2,2,5-Trisubstituted pyrrolidines are available from allylic pyroglutamates by Ireland-Claisen ester rearrangement followed by Eschenmoser sulfide contraction and reduction in a highly diastereoselective and efficient sequence. Some of the products from this sequence exhibit activity against S. aureus, but are much less active against E. coli.
No takes yet. Share an insight, caveat, or question.
Chandan et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: