Key result
Hydroxyethyl starch 200 kD reduced GP IIb-IIIa expression and thromboelastographic maximum amplitude, and prolonged platelet function analyzer-closure times compared to saline.
Why the study?
Does intravenous infusion of HES 200 kD affect platelet function in otherwise healthy patients scheduled for minor elective surgery?
Population
30 otherwise healthy patients scheduled for minor elective surgery (n=15 per group)
Comparison
Intravenous infusion of hydroxyethyl starch with… vs Intravenous infusion (10 mL/kg) of saline
Design
Other
Follow-up
Immediate (before and after infusion)
Authors
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May warrant caution with HES 200 kD in surgical patients; hypothesis-generating for clinical bleeding outcomes.
Does intravenous infusion of HES 200 kD affect platelet function in otherwise healthy patients scheduled for minor elective surgery?
Intravenous infusion of HES 200 kD impairs platelet function by decreasing the availability of platelet GP IIb-IIIa, which may explain its anticoagulant effects.
Stögermüller et al. (2000) studied otherwise healthy patients scheduled for minor elective surgery (n=30). Hydroxyethyl starch 200 kD vs. Saline was evaluated on Expression of glycoprotein (GP) IIb-IIIa, GP Ib, and P-selectin, thromboelastographic maximum amplitude (MA), and platelet function analyzer-closure times. Hydroxyethyl starch 200 kD reduced GP IIb-IIIa expression and thromboelastographic maximum amplitude, and prolonged platelet function analyzer-closure times compared to saline.
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