Key result
Impaired left ventricular global longitudinal strain (>-14.4%) was independently associated with increased all-cause mortality compared to GLS ≤-14.4% (HR 2.07; P=0.02).
Why the study?
Does impaired left ventricular global longitudinal strain (LV GLS >-14.4%) predict increased mortality and heart failure hospitalization in STEMI patients with COPD?
Population
143 STEMI patients with chronic obstructive pulmonary disease (COPD), mean age 70 ± 11 years, 71% male.
Comparison
Impaired left ventricular global longitudinal… vs Less impaired left ventricular global…
Design
Cohort
Follow-up
median 68 (interquartile range 38.5-99) months
Authors
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May refine risk stratification beyond LVEF in STEMI with COPD; hypothesis-generating, prospective trials needed before practice change.
Cohort (n=143)
Does impaired left ventricular global longitudinal strain (LV GLS >-14.4%) predict increased mortality and heart failure hospitalization in STEMI patients with COPD?
Hazard Ratio: 2.07
Absolute Event Rate: 44% vs 18%
p-value: p=0.02
Impaired left ventricular global longitudinal strain (>-14.4%) provides incremental prognostic value over LVEF for predicting long-term mortality and heart failure hospitalization in STEMI patients with COPD.
Goedemans et al. (2018) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) with chronic obstructive pulmonary disease (COPD) (n=143). Impaired left ventricular global longitudinal strain (>-14.4%) vs. LV GLS ≤-14.4% was evaluated on all-cause mortality (HR 2.07, p=0.02). Impaired left ventricular global longitudinal strain (>-14.4%) was independently associated with increased all-cause mortality compared to GLS ≤-14.4% (HR 2.07; P=0.02).
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