Key result
SVD-VLP isotype ELISAs demonstrated high diagnostic specificities (98.7% for IgM and 99.6% for IgG) and significantly reduced false-positive results compared to standard cELISA.
Why the study?
Standard competitive ELISA for swine vesicular disease antibody testing produces false-positive results, causing problems in international trade.
The newly developed SVD-VLP isotype ELISAs demonstrate high specificity and can effectively reduce false-positive results in swine vesicular disease testing.
Authors
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May improve SVD diagnostic accuracy by reducing false positives; leaves open validation in field conditions before routine adoption.
Yang et al. (2019) studied Swine vesicular disease (SVD) (n=319). SVD-VLP isotype antibody ELISAs vs. Competitive ELISA (cELISA) was evaluated on Diagnostic specificity and false-positive rate. SVD-VLP isotype ELISAs demonstrated high diagnostic specificities (98.7% for IgM and 99.6% for IgG) and significantly reduced false-positive results compared to standard cELISA.