Key result
Novel 3B cELISA outperforms comparator assay with ~100% sensitivity for detecting FMDV antibodies in cattle.
Population
Serum samples from cloven-hoofed animals including 16 experimentally infected with FMDV, 55 VSV-positive…
Design
Preclinical
Authors
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May support rapid FMDV serosurveillance in livestock; leaves open field validation before routine diagnostic use.
Absolute Event Rate: 100% vs 98.4%
A novel rapid competitive ELISA demonstrates high sensitivity and specificity for detecting FMDV antibodies, with the ability to differentiate infected from vaccinated animals.
Chung et al. (2018) studied Foot-and-mouth disease virus (FMDV) infection. 3B competitive ELISA (cELISA) vs. PrioCHECK FMDV NS antibody ELISA was evaluated on Diagnostic sensitivity (DSe) in cattle. The novel 3B cELISA demonstrated 100% diagnostic sensitivity and 99.4% diagnostic specificity for detecting FMDV antibodies in cattle sera, outperforming the comparator assay.
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