Key result
A novel competitive ELISA for detecting antibodies to FMDV serotype A demonstrated a diagnostic specificity of 99.7% and a sensitivity of 99.3%, showing strong agreement with the virus neutralization test.
The developed cELISA using two novel mAbs provides a simple, reliable, and rapid alternative to the virus neutralization test for detecting antibodies against FMDV serotype A.
No takes yet. Share an insight, caveat, or question.
May serve as high-throughput alternative to VNT; leaves open field validation across serotypes and populations.
Yang et al. (2016) studied Foot-and-mouth disease virus serotype A (n=1,174). Competitive ELISA (cELISA) for FMDV serotype A vs. Virus neutralization test (VNT) was evaluated on Diagnostic sensitivity (95% CI 98.5-100). A novel competitive ELISA for detecting antibodies to FMDV serotype A demonstrated a diagnostic specificity of 99.7% and a sensitivity of 99.3%, showing strong agreement with the virus neutralization test.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: