Key result
Phylogenetic analysis of type O foot-and-mouth disease virus VP1 sequences revealed four main lineages correlating with geographical origin and showed synonymous mutations drive its evolution.
Phylogenetic analysis of type O FMDV VP1 sequences reveals four main geographical lineages and highlights the role of synonymous mutations in viral evolution.
Geographic lineages may inform FMD surveillance; leaves open functional roles of synonymous mutations.
A phylogenetic tree based on the VPI sequences of type O foot-and-mouth disease virus (FMDV) has been derived. Direct sequencing of PCR products has been used to obtain the VP1 gene sequences of new isolates. The tree exhibits four main lineages that largely correlate with the geographical origin of isolates. The analysis supports a close relationship between European O1 field isolates and vaccine strains, with the exception of O Thalheim Aus/81 and O Wuppertal Ger/82 which were probably of non-European origin. Analysis of nucleotide substitutions indicates that synonymous mutations play a major role in FMDV evolution.
No takes yet. Share an insight, caveat, or question.
Sáiz et al. (1993) studied Foot-and-mouth disease virus type O. Phylogenetic analysis of VP1 sequences was evaluated on Phylogenetic lineages and nucleotide substitutions. Phylogenetic analysis of type O foot-and-mouth disease virus VP1 sequences revealed four main lineages correlating with geographical origin and showed synonymous mutations drive its evolution.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: