Platelets and Thrombosis

Editorials1 March 1966Platelets and ThrombosisM. F. GLYNN, M.D., F.R.C.P.(C), E. A. MURPHY, M.D., J. F. MUSTARD, M.D. F.R.C.P.(C)M. F. GLYNN, M.D., F.R.C.P.(C), E. A. MURPHY, M.D., J. F. MUSTARD, M.D. F.R.C.P.(C)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-715 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe characteristics of thrombi, in particular arterial thrombi, were delineated during the latter part of the nine-teenth century. It was shown that the initial step involved the formation of platelet aggregates (1-3). Further growth led to a structure consisting of masses of platelets interspersed with layers of fibrin and red blood cells (3). Within hours the platelet mass usually diminishes, and fibrin becomes the prominent component (3, 4). In man, thrombus material is usually not available until much of this transformation has occurred. Thus, there has been a tendency to lose sight of the basic importance of the platelet. Rightly...References1. BIZZOZERO G: Ueber einen neuen Formbestandtheil des Blutes und dessen Rolle bei der Thrombose under der Blutgerinnung. Virchow. Arch. Path. Anat. 90: 261, 1882. CrossrefGoogle Scholar2. EBERTHSCHIMMELBUSCH JCC: Die Thrombose nach Versuchen u. Leichenbefunden. Ferdinand Enke, Stuttgart, 1888. Google Scholar3. WELCH WH: The structure of white thrombi. Tr. Path. Soc. Philadelphia 13: 25, 1887. Google Scholar4. JØRGENSEN L: Experimental platelet and coagulation thrombi. Acta Path. Microbiol. Scand. 62: 189, 1964. CrossrefMedlineGoogle Scholar5. ZUCKERBORRELLI MBJ: Platelet dumping produced by connective tissue suspensions and by collagen. Proc. Soc. Exp. Biol. Med. 109: 779, 1962. CrossrefGoogle Scholar6. HOVIG T: Aggregation of rabbit blood platelets produced in vitro by saline "extract" of tendons. Thromb. Diath. Haemorrh. 9: 248, 1963. Google Scholar7. 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Author, Article, and Disclosure InformationAffiliations: Blood and Vascular Disease Research Unit Departments of Medicine and Pathology University of Toronto Toronto 5, Ontario PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOrganolead CompoundsPathology of reversed passive Arthus reaction in the chickenEffect of anticoagulants and inhibitors of platelet aggregation on thrombotic occlusion of endarterectomized cat carotid arteries.The Experimental Evaluation of Prophylaxis in Venous Thrombosis by the Use of Antiplatelet AgentsAlterations in platelet aggregation associated with adjuvant arthritis in ratsRelation of microcirculatory thrombosis to thrombus in the proximal coronary artery: Effect of aspirin, dipyridamole, and thrombolysisThrombogenic Properties of Vascular Catheter Materials in VitroEffect of aspirin upon experimental coronary and non-coronary thrombosis and arrhythmiaInhibition of the Function of Human Blood Platelets in vitro by VK 744Platelet adhesiveness, plasma fibrinogen and factor VIII levels in diabetes mellitusProblems with various perfusates for kidney preservationThe coronary circulation and conduction system in acute myocardial infarctionPathology of small coronary arteries 1 March 1966Volume 64, Issue 3Page: 715-719KeywordsFibrinPlateletsRed blood cellsThrombosis Issue Published: 1 March 1966 PDF DownloadLoading ...