Key result
This review summarizes the current literature on acute flaccid myelitis associated with enterovirus D68, discussing its clinical presentation, treatment modalities, and ongoing research.
Why the study?
Recent biennial epidemics of acute flaccid myelitis have been associated with enterovirus D68, but the underlying pathophysiology is unknown.
This review summarizes the current literature, clinical presentation, and treatment modalities for acute flaccid myelitis associated with enterovirus D68.
Supports heightened clinical vigilance for EV-D68-associated AFM in children; leaves optimal management strategies open for prospective trials.
Acute flaccid myelitis is a disease that affects the anterior horn cells of the spinal cord, leading to rapid onset of flaccid paralysis. Recent biennial epidemics, beginning in the summer of 2014, have been associated with enterovirus D68, although the underlying pathophysiology is unknown. Patients present with asymmetric flaccid weakness of the extremities, with cranial neuropathy and without encephalopathy, and often have residual disability. Here we review the current literature on this disabling disease and discuss treatment modalities and ongoing research.
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Christy et al. (2019) conducted a review in Acute flaccid myelitis. This review summarizes the current literature on acute flaccid myelitis associated with enterovirus D68, discussing its clinical presentation, treatment modalities, and ongoing research.
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