Key result
Female patients with hypertensive heart disease had a significantly higher likelihood of having cancer compared to male patients (53.8% vs 18.4%, p=0.000662).
Why the study?
Cardiovascular disease and cancer are leading causes of noncommunicable death worldwide, but data on the coincidence of cancer in patients with hypertensive heart disease were needed.
Cross-Sectional (n=90)
No
Absolute Event Rate: 53.8% vs 18.4%
p-value: p=0.000662
In a cross-sectional study of patients with hypertensive heart disease, female sex was significantly associated with a higher prevalence of cancer, whereas the duration of hypertension showed no significant association.
May suggest HHD-cancer cell behavior parallels; leaves open whether shared mechanisms warrant targeted trials.
Hypertenze jako globĂĄlnĂ zdravotnickĂ˝ problĂŠm stĂĄle nenĂ dostateÄnÄ lĂŠÄena; vĂ˝sledkem jsou zmÄny ve struktuĹe a funkci srdce, kterĂŠ jsou spojeny s hypertenznĂ nemocĂ srdce (hypertensive heart disease, HHD). PĹitom se pĹi nĂĄdorovĂŠm onemocnÄnĂ s charakteristickou abnormĂĄlnĂ proliferacĂ bunÄk zaÄĂnajĂ buĹky chovat jinak a jinak odpovĂdat na lĂŠÄebnĂŠ strategie. PĹes znaÄnĂŠ ĂşsilĂ zĹŻstĂĄvajĂ nÄkterĂŠ druhy nĂĄdorĹŻ nevylĂŠÄitelnĂŠ, coĹž znamenĂĄ, Ĺže kardiovaskulĂĄrnĂ onemocnÄnĂ a nĂĄdorovĂĄ onemocnÄnĂ pĹedstavujĂ celosvÄtovÄ hlavnĂ pĹĂÄiny ĂşmrtĂ na nepĹenosnĂĄ onemocnÄnĂ. Ve snaze zĂskat dalĹĄĂ informace o tĂŠto shodÄ jsme provedli prĹŻĹezovou studii incidence nĂĄdorovĂ˝ch onemocnÄnĂ u pacientĹŻ s HHD lĂŠÄenĂ˝ch ve vĹĄeobecnĂŠ nemocnici dr. Soetoma. PrĹŻmÄrnĂ˝ vÄk hodnocenĂŠ populace byl 58,1 roku a prĹŻmÄrnĂĄ hodnota BMI 25,9. Nalezli jsme statisticky vĂ˝znamnou spojitost mezi pohlavĂm a dobou od stanovenĂ diagnĂłzy hypertenze na jednĂŠ stranÄ a pĹĂtomnostĂ nĂĄdorovĂŠho onemocnÄnĂ u populace s HHD na stranÄ druhĂŠ. ZĂskanĂŠ Ăşdaje konkrĂŠtnÄ ukazujĂ, Ĺže u Ĺžen s HHD existuje vyĹĄĹĄĂ pravdÄpodobnost vzniku nÄkterĂ˝ch typĹŻ karcinomĹŻ, zvlĂĄĹĄtÄ prsu a gynekologickĂ˝ch. DalĹĄĂ typy nĂĄdorĹŻ byly nalezeny v prostatÄ, krvi a v lymfatickĂŠm systĂŠmu, hlavÄ a krku, v plicĂch, ĹĄtĂtnĂŠ ĹžlĂĄze a v ledvinĂĄch. AnalĂ˝za nicmĂŠnÄ neprokĂĄzala spojitost mezi dobou od stanovenĂ diagnĂłzy hypertenze a prevalencĂ nĂĄdorovĂŠho onemocnÄnĂ. Za zmĂnku stojĂ zvlĂĄĹĄtÄ zjiĹĄtÄnĂ starĹĄĂch studiĂ, Ĺže korelace mezi nĂĄdorovĂ˝m onemocnÄnĂm a hypertenzĂ nesouvisĂ s uĹžĂvĂĄnĂm antihypertenziv, protoĹže stejnĂŠ riziko lze pozorovat i u nelĂŠÄenĂ˝ch pacientĹŻ. NÄkolik rizikovĂ˝ch faktorĹŻ spoleÄnĂ˝ch pro hypertenzi a nĂĄdorovĂĄ onemocnÄnĂ ukazuje na pĹekryv zĂĄkladnĂch molekulĂĄrnĂch patofyziologickĂ˝ch mechanismĹŻ obou onemocnÄnĂ. BudoucĂ, lĂŠpe navrĹženĂŠ studie se musejĂ zamÄĹit na dalĹĄĂ spoleÄnĂŠ faktory hypertenze a nĂĄdorovĂ˝ch onemocnÄnĂ u vÄtĹĄĂch souborĹŻ pacientĹŻ.
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Ardiana et al. (2024) conducted a cross-sectional in Hypertensive heart disease (n=90). Female sex vs. Male sex was evaluated on Presence of cancer (p=0.000662). Female patients with hypertensive heart disease had a significantly higher likelihood of having cancer compared to male patients (53.8% vs 18.4%, p=0.000662).
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