Key result
Superfusion with L-NNA and TBA generally reduced complexity indices of red cell velocity and arteriolar diameter fluctuations compared to control conditions in anaesthetized rats.
Population
Anaesthetized rats (mesenteric bed)
Comparison
Local superfusion with NG-nitro-L-arginine and… vs Control conditions
Design
Preclinical
Authors
Loading...
Animal data implicate NO and KCa channels in microvascular complexity; leaves open translation to human microcirculation.
Suppression of NO synthesis and blockade of calcium-activated potassium channels reduces the complexity of microvascular flow fluctuations in the rat mesenteric bed.
Parthimos et al. (2004) studied this question. NG-nitro-L-arginine (L-NNA) and tetrabutylammonium (TBA) vs. Control conditions was evaluated on Correlation dimensions and largest Lyapunov exponents. Superfusion with L-NNA and TBA generally reduced complexity indices of red cell velocity and arteriolar diameter fluctuations compared to control conditions in anaesthetized rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: