Key result
Short-term enhancement of atrial IKs by angiotensin II shortens action potential duration and may contribute to the very early phase of atrial electrical remodeling.
Short-term enhancement of atrial IKs by angiotensin II may contribute to early atrial electrical remodeling, while long-term antifibrotic effects of ARBs prevent atrial fibrillation.
We thank Dr Christ and his colleagues very much for their interest in our article. We attempted to contend that the short-term enhancement of atrial I Ks by angiotensin II (Ang II) shortens the action potential duration (APD) and may contribute to the very early phase of atrial electrical remodeling. We fully agree that the antifibrotic effects may represent the principal mechanism by which Ang II type 1 receptor blockers prevent atrial fibrillation (AF), but the difference between short-term and long-term phases of atrial remodeling should also be considered.
No takes yet. Share an insight, caveat, or question.
Zankov et al. (2006) conducted a letter in Atrial electrical remodeling / Atrial fibrillation. Angiotensin II was evaluated. Short-term enhancement of atrial IKs by angiotensin II shortens action potential duration and may contribute to the very early phase of atrial electrical remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: