Key result
Blood vessel bifurcation ratios determine the maximum shear rate on a growing thrombus, and ratios adhering to Murray's law may protect against occlusive thrombus formation.
Why the study?
Vascular geometry determines hemodynamics affecting vessel occlusion from thrombus formation, with bifurcations introducing flow separation between parent and daughter vessels.
Analytical modeling demonstrates that vascular bifurcation ratios dictate shear rates during thrombus formation, with Murray's law ratios potentially offering protection against occlusion.
Vascular geometry is a major determinant of the hemodynamics that promote or prevent unnecessary vessel occlusion from thrombus formation. Bifurcations in the vascular geometry are repeating structures that introduce flow separation between parent and daughter vessels. We modelled the blood flow and shear rate in a bifurcation during thrombus formation and show that blood vessel bifurcation ratios determine the maximum shear rate on the surface of a growing thrombus. We built an analytical model that may aid in predicting microvascular bifurcation ratios that are prone to occlusive thrombus formation. We also observed that bifurcation ratios that adhere to Murray's law of bifurcations may be protected from occlusive thrombus formation. These results may be useful in the rational design of diagnostic microfluidic devices and microfluidic blood oxygenators.
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Lakshmanan et al. (2019) studied Occlusive thrombus formation. Blood vessel bifurcation ratio was evaluated on Maximum shear rate on the surface of a growing thrombus. Blood vessel bifurcation ratios determine the maximum shear rate on a growing thrombus, and ratios adhering to Murray's law may protect against occlusive thrombus formation.
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