The cross-protection technique failed to clearly differentiate the types of receptors involved in the action of sympathomimetic amines in the rabbit aorta.
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Inconclusive on receptor subtypes in ileum and aorta; leaves open functional classification of inhibitory versus excitatory sympathomimetics.
Some sympathomimetic amines act on 5-hydroxytryptamine receptors in certain preparations of gut-for example, rat stomach Using cross-protection against phenoxybenzamine as a means of differentiating drug receptors, Innes (1963) concluded that dexamphetamine acted on 5-hydroxytryptamine receptors in guinea-pig ileum and other smooth muscles including vascular smooth muscle. To extend this conclusion to other sympathomimetic amines, which stimulated guinea-pig ileum and seemed to act on 5-hydroxytryptamine receptors in that tissue, an attempt was made to differentiate receptors for a few sympathomimetic amines in the rabbit aorta by using the cross-protection technique. The results obtained did not enable any clear-cut conclusion to be drawn regarding the type of receptors involved in the action of sympathomimetic amines classed as "inhibitory" and "excitatory" according to their action on guinea-pig ileum (Kohli, 1965).
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J D Kohli (1968) studied this question.
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