Median and ulnar neuropathy in the guinea-pig.

In the course of some earlier experiments involving the measurement of conduction velocity in the motor nerves of the guinea-pig, it was discovered by chance that conduction in the median nerve was frequently abnormal in animals which were more than 18 months old. Subsequently it became ap-parent that this was due to a local lesion of the median or the ulnar nerve at the wrist, which could develop during adult life in otherwise healthy ani-mals (Fullerton and Gilliatt, 1966). This phenomenon has now been further investigated. METHODS Healthy male and female guinea-pigs were used. Most of the young animals, aged 4-8 months, werebred in our own laboratory. Old guinea-pigs were obtained from the