Key result
The current IPV schedule with the first dose at 6 months resulted in the highest persisting antibody titers against PV1 and PV2 at 3 years of age compared to earlier onset schedules (P < 0.001).
Why the study?
Do different three-dose schedules of inactivated poliovirus vaccine affect antibody responses in children?
Population
Five groups of children
Comparison
Different three-dose schedules of inactivated… vs Control group immunized with the current schedule
Design
Cohort
Follow-up
Up to 3 years of age
Authors
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Later IPV initiation may optimize persisting titers; leaves open optimal scheduling pending randomized trials.
Do different three-dose schedules of inactivated poliovirus vaccine affect antibody responses in children?
p-value: p=<0.001
Three doses of IPV provide satisfactory immune responses, but very early onset and short dosage intervals should be avoided for optimal persisting antibody levels.
Sormunen et al. (2001) studied Polio immunization. Inactivated poliovirus vaccine (IPV) in early onset schedules vs. Current schedule (first dose at 6 months) was evaluated on Persisting antibody titers against PV1, PV2, and PV3 at 3 years of age (p=<0.001). The current IPV schedule with the first dose at 6 months resulted in the highest persisting antibody titers against PV1 and PV2 at 3 years of age compared to earlier onset schedules (P < 0.001).
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