Key result
GM-CSF-induced monocyte differentiation increased EMMPRIN mRNA 5- to 8-fold relative to undifferentiated monocytes, and EMMPRIN was observed in macrophage-rich areas of human coronary atheroma.
Population
Human peripheral blood monocytes (HPBM) and human coronary atherosclerotic samples
Comparison
GM-CSF-induced monocyte differentiation and… vs Undifferentiated monocytes and nonlipid-loaded…
Design
Preclinical
Follow-up
10 days (in vitro)
Authors
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May support EMMPRIN in atherogenesis; hypothesis-generating and requires validation before clinical consideration.
Effect estimate: 5- to 8-fold increase
EMMPRIN is upregulated during monocyte-to-macrophage differentiation and is expressed in human atheroma, suggesting a role in atherosclerosis development.
Major et al. (2002) studied Atherosclerosis. GM-CSF-induced monocyte differentiation vs. Undifferentiated monocytes was evaluated on EMMPRIN mRNA expression (5- to 8-fold increase). GM-CSF-induced monocyte differentiation increased EMMPRIN mRNA 5- to 8-fold relative to undifferentiated monocytes, and EMMPRIN was observed in macrophage-rich areas of human coronary atheroma.
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