Why the study?
Obstructive sleep apnoea is associated with increased cardiovascular disease risk, with alterations in coagulability suspected as the mediating factor.
Population
903 patients diagnosed by standard polysomnography
Comparison
Coagulation parameters across sleep-related breathing metrics
Design
Cross-sectional observational study
Key result
Obstructive sleep apnoea severity, specifically the oxygen desaturation index, was associated with an increased risk of platelet distribution width abnormalities (OR 1.009, p=0.009).
Authors
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OSA severity-associated coagulation shifts may heighten thrombotic risk; leaves open causal mediation of CV events and need for longitudinal studies.
Cross-Sectional (n=903)
No
Odds Ratio: 1.009
p-value: p=0.009
Increasing severity of obstructive sleep apnea is associated with alterations in platelet activation and coagulation parameters, potentially mediating the increased cardiovascular risk in these patients.
Xue et al. (2023) conducted a cross-sectional in Obstructive sleep apnoea (n=903). Obstructive sleep apnoea was evaluated on Risk of platelet distribution width (PDW) abnormalities (OR 1.009, p=0.009). Obstructive sleep apnoea severity, specifically the oxygen desaturation index, was associated with an increased risk of platelet distribution width abnormalities (OR 1.009, p=0.009).