Key result
Implementation science frameworks and targeted trial designs optimize GDMT delivery in heart failure care.
Why the study?
Despite highest-quality evidence supporting guideline-directed medical therapy to improve heart failure outcomes, implementation of this evidence has been suboptimal.
Answers are grounded in this paper and cite their sources.
Adopting principles of implementation science and robust trial designs can improve the suboptimal uptake of guideline-directed medical therapy in heart failure.
Condensed Abstract Heart failure (HF) is a leading cause of death and disability in older adults. Despite highest-quality evidence that supports the use of guideline-directed medical therapy (GDMT) to improve outcomes in HF, implementation of this evidence has been suboptimal. This review synthesizes implementation interventions that increase the uptake of GDMT, discusses barriers and facilitators of implementation, summarizes conceptual frameworks in implementation science that could improve knowledge uptake, and offers suggestions for trial design that could better facilitate long-term implementation. By adopting principles of implementation science, policy makers, researchers, and clinicians can reduce the burden of HF on patients and healthcare systems.
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Jalloh et al. (2023) conducted a review in Heart failure. Implementation strategies for guideline-directed medical therapy was evaluated. Implementation science frameworks and robust trial designs can bridge the gap between evidence and clinical care for guideline-directed medical therapy in heart failure.
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